Robert Downey Jr. and Susan Downey Pictures: Sherlock Holmes: A Game of Shadows Premiere Photos, Pics

Robert Downey Jr. and Susan Downey Pictures: Robert Downey Jr. and wife Susan Downey attends the "Sherlock Holmes: A Game of Shadows" movie premiere held at the Regency Village Theatre on December 6, 2011 in Westwood, California.

Sherlock Holmes has always been the smartest man in the room... until now. There is a new criminal mastermind at large - Professor Moriarty - and not only is he Holmes' intellectual equal, but his capacity for evil, coupled with a complete lack of conscience, may actually give him an advantage over the renowned detective. Holmes' investigation into Moriarty's plot becomes ever more dangerous as it leads him and Watson out of London and across Europe, to France, Germany and finally to Switzerland. But the cunning Moriarty is always one step ahead as he spins a web of death and destruction - all part of a greater plan that, if he succeeds, will change the course of history.

"Sherlock Holmes: A Game of Shadows" opens in theaters on December 16.

Photo credit: Andrew Evans / PR Photos