19-year-old Alice returns to the whimsical world she first encountered as a young girl, reuniting with her childhood friends: the White Rabbit, Tweedledee and Tweedledum, the Dormouse, the Caterpillar, the Cheshire Cat, and of course, the Mad Hatter. Alice embarks on a fantastical journey to find her true destiny and end the Red Queen's reign of terror.

Two U.S. marshals, Teddy Daniels and Chuck Aule, are summoned to a remote and barren island off the coast of Massachusetts to investigate the mysterious disappearance of a murderess from the island's fortress-like hospital for the criminally insane.