As if Arizona hasn't already had a rough year, Thursday's episode of Grey's Anatomy will see her stricken with an ailment that could be incurable: phantom limb syndrome.

How will Arizona handle the latest hurdle since her amputation? TVGuide.com caught up with Jessica Capshaw, who also discusses how the plane crash survivors may be able to save Seattle Grace and Callie (Sara Ramirez) and Arizona's future. Get the scoop:

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• Justin Chambers
• Kevin McKidd
• Chandra Wilson
• Jessica Capshaw
• Grey's Anatomy
• Sara Ramirez
• Shonda Rhimes